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Acute Blood Purification
von: H. Suzuki, H. Hirasawa
Karger, 2010
ISBN: 9783805594790 , 204 Seiten
Format: PDF, ePUB, OL
Kopierschutz: DRM
Preis: 133,28 EUR
Cover
1
Contents
6
Preface
9
Introduction
10
References
12
Current Status
13
Current Status of Blood Purification in Critical Care in Japan
13
Abstract
13
Methods
14
Results
15
Discussion
16
Acknowledgement
18
References
18
Terminology and Indication
20
Terminology and Classification of Blood Purification in Critical Care in Japan
20
Abstract
20
Expressions of Blood Purification in Critical Care
21
Definitions of Continuous and Intermittent Therapies
22
Classification Based on the Purification Mode Using a Hemofilter
23
Classification of Blood Purification Based on the Blood Drawing and Returning Routes
23
Selection of CHD, CHF and CHDF Based on the Elimination Efficiency
24
Expressions Used when the Volume of Blood Purification Is Increased Intentionally above the Standard Level
25
Expressions Based on the Administration Route of Substitution Fluid
26
Terms used to Express Flow Rates
26
Classification and Expressions of Hemofilters
27
Conclusion
28
References
28
Indications for Blood Purification in Critical Care
30
Abstract
30
Blood Purification in Intensive Care Units
30
Indications for Blood Purification in ICU
31
Blood Purification for Hypercytokinemia and Sepsis
33
Future Perspectives
35
References
37
Acute Renal Failure
40
Acute Kidney Injury of Non-Septic Origin Requiring Dialysis Therapy
40
Abstract
40
Pathogenesis of AKI in Cardiovascular Surgery
40
Predictive Factors for the Risk of Postoperative Dialysis
41
Intraoperative Events
42
Postoperative Events
43
Beginning Dialysis Therapy
43
Conclusion
47
References
47
Septic Acute Renal Failure
49
Abstract
49
Pathophysiology
50
Therapy
51
References
53
Non-renal Indication
56
Non-Renal Indications for Continuous Renal Replacement Therapy: Current Status in Japan
56
Abstract
56
Blood Purification Advances in Japan
57
PMMA-CHDF
59
Plasma Diafiltration
59
Online CHDF
60
Cytokine-Adsorbing Column
60
Future Perspectives
60
References
61
Continuous Hemodiafiltration Using a Polymethyl Methacrylate Membrane Hemofilter for SevereAcute Pancreatitis
63
Abstract
63
Evaluation of the Magnitude of Hypercytokinemia in Patients with SAP
64
Criteria for Initiation of and Weaning from PMMA-CHDF
65
Effects of PMMA-CHDF on Blood IL-6 Level, Clinical Parameters and Outcome
68
Effects of PMMA-CHDF on Abdominal Compartment Syndrome
69
PMMA-CHDF as a Means of Cytokine Modulation
70
Conclusion
71
References
71
Blood Purification in Fulminant Hepatic Failure
73
Abstract
73
Purpose of Blood Purification
74
Hemodialysis and Hemofiltration
75
Plasmapheresis
76
Molecular Adsorbents Recirculating System
77
Bioartificial Liver Devices
77
Clinical Implementation of Blood Purification in Our Group
77
Conclusions
80
References
80
Treatment of Severe Sepsis and Septic Shock by CHDF Using a PMMA Membrane Hemofilter as a Cytokine Modulator
82
Abstract
82
Procedures in PMMA-CHDF for the Treatment of Severe Sepsis/Septic Shock
83
Cytokine-Removing Effects of PMMA-CHDF
84
Therapeutic Effects of Early Implementation of PMMA-CHDF in Septic Shock
84
Immunomodulatory Effects of Cytokine Removal by PMMA-CHDF on Immunocompetent Cells
87
Enhancement of the Cytokine-Removing Capacity of PMMA-CHDF to Cope with Refractory Septic Shock
89
Conclusion
89
References
90
Efficacy of Continuous Hemodiafiltration with a Cytokine-Adsorbing Hemofilter in the Treatment of Acute Respiratory Distress Syndrome
92
Abstract
92
Materials and Methods
93
Results
95
Discussion
98
Conclusions
100
References
100
Blood Purification for Intoxication
102
Abstract
102
Indications for Blood Purification
103
Approach to Protein-Binding Substances
105
Case Presentation
106
Conclusion
108
References
108
Current Progresses in Methodology in Blood Purification in Critical Care
109
Current Progress in Blood Purification Methods Used in Critical Care Medicine
109
Abstract
109
Application of Blood Purification in Critical Care
110
Characteristics of Blood-Purification Methods Used in Critical Care
114
References
118
Membrane Materials for Blood Purification in Critical Care
121
Abstract
121
Materials and Methods
122
Results and Discussion
124
Conclusions
127
References
127
Anticoagulation in Acute Blood Purification for Acute Renal Failure in Critical Care
128
Abstract
128
Indications for Acute Blood Purification in Critical Care Patients
129
Modalities in Acute Blood Purification for ARF and Their Anticoagulation
129
Anticoagulation in Acute Blood Purification for ARF
131
Unfractionated Heparin
131
LMW Heparin
133
Nafamostat Mesilate
133
References
134
Equipment and Monitoring in Continuous Renal Replacement Therapy
135
Abstract
135
Selection of the Console System in CRRT
135
Composition and Monitoring of the CRRT Console
136
Management of CRRT Console System
141
References
142
Cytokine Adsorbing Columns
143
Abstract
143
CytoSorb Cartridge
145
CYT-860-DHP
145
Lixelle Column
146
CTR-001 Column
147
MPCF-X
148
Discussion
148
References
149
Plasma Dia-Filtration for Severe Sepsis
151
Abstract
151
Patients and Methods
152
Results
154
Discussion
156
Acknowledgement
157
References
157
Application of Polymyxin B Convalently Immobilized Fiber in Patients with Septic Shock
159
Abstract
159
Designing PMX
160
Animal Experiments
161
Clinical Studies
161
Drawbacks of Treatment with PMX-F
164
RCT of Treatment with PMX-F in Patients with Sepsis
164
Conclusion
165
References
165
Special Considerations in Continuous Hemodiafiltration with Critically Ill Pediatric Patients
167
Abstract
167
Advantages of CHDF over Intermittent Hemodialysis
168
CHDF Conditions for Pediatric Patients
168
Efficacy and Indications for CHDF in Pediatric Patients
168
Problems of CHDF in Pediatric Patients
169
Countermeasures to Problems Associated with CHDF in Pediatric Patients
169
Conclusions
174
References
174
Controversies in Blood Purification in Critical Care
176
Selection of Modality in Continuous Renal Replacement Therapy
176
Abstract
176
Modality in Continuous Renal Replacement Therapy (CRRT)
176
Selection of Modality in CRRT: Survival in ICU Acute Renal Failure
177
Efficacy of CRRT in Other Conditions
178
Conclusions
180
References
180
Online CHDF System: Excellent Cost-Effectiveness for Continuous Renal Replacement Therapy with High Efficacy and Individualization
182
Abstract
182
Methods and Results
183
Discussion
186
Conclusion
188
References
189
New Technology
190
‘Super High-Flux’ or ’High Cut-Off’Hemofiltration and Hemodialysis
190
Abstract
190
SHF/HCO Hemofiltration
191
Ex vivo Findings with SHF/HCO Membranes
192
Pilot Clinical Study of SHF/HCO Hemofiltration
193
Effect of SHF/HCO Membrane on Cellular Function
193
Albumin Loss and Safety Issues
194
HCO Hemodialysis
195
Another Therapeutic Target: HMGB-1 and SHF/HCO Membrane
196
Conclusions
197
References
197
Author Index
199
Subject Index
200
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