Milk and Milk Products in Human Nutrition

Milk and Milk Products in Human Nutrition

von: R.A. Clemens, O. Hernell, K.F. Michaelsen

Karger, 2011

ISBN: 9783805595872 , 234 Seiten

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Milk and Milk Products in Human Nutrition


 

Milk and Milk Products in Human Nutrition

2

Contents

6

Preface

8

Foreword

9

Contributors

12

Milk during Pregnancy and Infancy

15

Milk Intake, Calcium and Vitamin D inPregnancy and Lactation: Effects onMaternal, Fetal and Infant Bone inLow- and High-Income Countries

15

Abstract

15

Introduction

15

Calcium as a Bone-Forming Mineral

16

Calcium Requirements for Infancy, Pregnancy and Lactation

16

Vitamin D Requirements for Infancy, Pregnancy and Lactation

17

Dietary Sources and Intakes of Calcium

18

Dietary Sources and Intakes of Vitamin D

19

Animal Milk Consumption in Low- and High-Income Countries

20

Implications of a Low Calcium Intake for Maternal and InfantBone Health

20

Implications of a Low Vitamin D Supply for Maternal and InfantBone Health

22

Animal Milk Intake in Pregnancy and Lactation

22

Conclusions

22

Acknowledgments

23

References

23

Discussion

25

References

29

Human Milk vs. Cow’s Milk and theEvolution of Infant Formulas

31

Abstract

31

Introduction

31

Principal Differences between Human Milk and Cow’s Milk

32

The History of Infant Formulas

33

Recent Modifications of Infant Formulas

35

References

38

Discussion

39

References

42

Whole Cow’s Milk in Early Life

43

Abstract

43

Cow’s Milk in Infancy and Iron Deficiency

43

Infant Formula instead of Whole Cow’s Milk

44

Whole Cow’s Milk and the Consequences of the High ProteinConcentration

46

Allergy and Cow’s Milk Protein

48

Cow’s Milk and Less Evident Hypothesis on Diabetes Type 1 andAutism

48

Conclusions

50

References

50

Discussion

51

References

54

Biological Effects of Novel BovineMilk Fractions

55

Abstract

55

Introduction

55

-Lactalbumin

56

Lactoferrin

58

Osteopontin

60

Milk Fat Globule Membrane Proteins

61

Conclusions

63

References

63

Discussion

65

Reference

68

Milk and Oral Health

69

Abstract

69

Oral Health in a Global Perspective

69

Determinants for Dental Caries

70

Potential Anticariogenic Effects of Milk

72

Milk and Dental Health in Children

72

Dairy Products and Oral Health in Adults

73

Milk as a Carrier of Therapeutic Agents

75

Conclusion

75

References

76

Discussion

77

Reference

80

Milk during Childhood in Low- and High-Income Countries

81

Milk and Growth in Children: Effects ofWhey and Casein

81

Abstract

81

Milk and Growth

84

Whey and Casein

85

Body Composition

86

Mechanism

86

References

88

Discussion

89

References

92

Milk and Linear Growth: Programming ofthe IGF-I Axis and Implication forHealth in Adulthood

93

Abstract

93

Introduction

93

Childhood Stature and Health in Adulthood

95

Breast Milk, Cows Milk and Stature

96

Milk and Health in Adulthood

97

Insulin-Like Growth Factors, Nutrition and Adult ChronicDisease Risk

99

Nutritional Programming of IGF-I

101

Implications

102

Acknowledgements

104

References

104

Discussion

107

References

110

Cow’s Milk in Treatment of Moderateand Severe Undernutrition inLow-Income Countries

113

Abstract

113

Introduction

113

Definition of Undernutrition

114

Size of the Undernutrition Problem

114

Why Is Milk So Effective?

115

Protein

115

Lactose

115

Minerals

116

Effects of Milk on Nutritional Status

116

Cow’s Milk Products Used in Treatment of Undernutrition

117

Products for Treating Undernutrition

118

Potential Negative Effects of Using Cow’s Milk

118

Recommendations on the Use of Milk in Treating Undernutrition

120

References

120

Discussion

122

Reference

125

Effects of Animal Source Foods, withEmphasis on Milk, in the Diet ofChildren in Low-Income Countries

127

Abstract

127

Introduction

127

Observational Studies

128

Intervention Trials

129

Milk from Other Animals

137

Unresolved Questions Concerning Cow’s Milk and Children’sHealth in Developing Countries

138

Conclusions

138

References

139

Discussion

141

Evidence for Acne-Promoting Effects ofMilk and Other Insulinotropic DairyProducts

145

Abstract

145

Epidemiological Evidence for the Relation between MilkConsumption and Acne

146

Combinations of Milk and Carbohydrates PotentiateInsulinotropic Effects

147

Milk Consumption Elevates Postprandial Insulinemia, GH andIGF-I Plasma Levels

147

Whey Proteins: The Major Inducers of PostprandialHyperinsulinemia

148

A Possible Role of Bovine Betacellulin in Acne Pathogenesis

148

Evidence for a Milk-Entero-Pituitary Axis?

150

Existence of a Milk-Pituitary-Adrenal-Sebocyte Axis?

151

Nutrigenomic Effects of Milk on FoxO1 Signaling in AcnePathogenesis

151

Acne-Cancer Relationship

152

Conclusion

154

References

154

Discussion

156

References

158

General Aspects of Milk: Milk in Adult Nutrition

161

Milk Proteins in the Regulation ofBody Weight, Satiety, Food Intakeand Glycemia

161

Abstract

161

Introduction

161

Dairy Consumption, Body Weight and the Metabolic Syndrome

162

Characteristics of Cow’s Milk Proteins

162

Milk Proteins, Satiety and Food Intake

164

Milk Proteins and Satiety Mechanisms

166

Milk Proteins and Glycemic Control

167

Conclusions

170

References

170

Discussion

171

Reference

173

Lactose Intolerance: An UnnecessaryRisk for Low Bone Density

175

Abstract

175

References

180

Discussion

181

Milk and the Risk and Progression ofCancer

187

Abstract

187

Introduction

187

Key Issues in Diet-Cancer Research

188

Colorectal Cancer

190

Prostate Cancer

192

Breast and Ovarian Cancer

193

Conclusions

196

References

196

Discussion

197

Reference

199

Milk A1 and A2 Peptides and Diabetes

201

Abstract

201

Introduction

201

Overview Dietary Peptides

202

Overview Diabetes

205

Dietary Peptides and Diabetes

206

Conclusion

207

References

208

Discussion

208

Milk Fat and Health Consequences

211

Abstract

211

Dairy Fat Composition

211

Saturated Fats and Cholesterol

211

Effect of Dairy Fats in the Diet

212

Trans Fatty Acids

214

Omega-3 Long-Chain Polyunsaturated Fatty Acids

214

Bioactive Phospholipids

215

Conclusions

216

References

216

Discussion

217

References

221

Concluding Remarks

223

Subject Index

229