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Hemodiafiltration - A New Era
von: H. Kawanishi, A.C. Yamashita
Karger, 2010
ISBN: 9783805595612 , 228 Seiten
Format: PDF, ePUB, OL
Kopierschutz: DRM
Preis: 236,81 EUR
Cover
1
Contents
6
Preface
9
History and Evolution of Hemodiafiltration
11
Dawn of Hemodiafiltration
11
Abstract
11
First 60 Years (1914 – Early 1970s)
11
Middle Molecule Hypothesis and HF
12
Development of HDF
12
The Current Status of HDF in Japan
13
References
14
Hemodiafiltration – State of the Art
15
Abstract
15
Online Hemodiafiltration
19
References
25
Hemodiafiltration: Evolution of a Technique towards Better Dialysis Care
29
Abstract
29
Hemodiafiltration: From Origin to Today
29
Techniques of Hemodiafiltration
30
Mechanism of Hemodiafiltration
33
Clinical Outcomes Achieved by HDF
34
Conclusion
36
References
36
Clinical Benefits of Hemodiafiltration
38
Optimal Therapeutic Conditions for Online Hemodiafiltration
38
Abstract
38
Technical Prerequisite and Basic Hygienic Rules for ol-HDF
39
Prerequisite and Technical Options of ol-HDF
41
ol-HDF Prescription in Practice
44
Handling and Microbial Monitoring of ol-HDF
44
Conclusions
45
References
45
Effect of Hemodiafiltration on Mortality, Inflammation and Quality of Life
49
Abstract
49
Mortality
50
Inflammation
51
Health-Related Quality of Life
55
Treatment Optimization Parameters
57
Conclusion
58
References
58
How to Prescribe Hemodialysis or Hemodiafiltration in Order to Ameliorate Dialysis-Related Symptoms and Complications
63
Abstract
63
Classical Parameters for Prescribing a Dialysis Modality
64
New Concept for Prescribing a Dialysis Modality
65
Results of the Dialysis Prescription Based on the POD System
66
Rationale of the New Concept for a Dialysis Prescription
67
Practice Pattern for Prescribing Online HDF from a Case Study
71
Conclusion
72
References
72
Optimizing Home Dialysis: Role of Hemodiafiltration
74
Abstract
74
Benefits of HDF over Low-Flux and High-Flux Hemodialysis
77
Individualizing Choice of Renal Replacement Therapy
79
Providing HDF at Home: Technical Considerations
80
Dialysis Adequacy for Home HDF
83
Equipment Portability
84
Conclusion
84
Acknowledgement
84
References
85
Management of Dialysis Fluid and Dialysis System
88
Quality Management of Dialysis Fluid for Online Convective Therapies
88
Abstract
88
Online Preparation of Substitution Solution for Convective Therapies
89
Components of a Quality Management System
91
References
97
Biocompatibility of Dialysis Fluid for Online HDF
99
Abstract
99
Purification of Online Preparation
100
Composition of Dialysis and Substitution Fluids
100
Methods
101
Results
103
Discussion
105
Conclusion
106
References
107
Characteristics of Central Dialysis Fluid Delivery System and Single Patient Dialysis Machine for HDF
109
Abstract
109
Central Dialysis Fluid Delivery System in Japan
109
SPDM in Japan
112
Substitution Fluid for Online HDF with CDDS and SPDM
113
Maintenance of Purification of Dialysis Fluid
114
HD and/or Online HDF Using SPDM by Comprehensive Management
115
Conclusion
116
References
116
Fully Automated Dialysis System for Online Hemodiafiltration Built into the Central Dialysis Fluid Delivery System
117
Abstract
117
Outline of the Central Dialysis Delivery System
118
FADS with Online HDF
119
Fully Automated Dialysis System
119
Dialysis Fluid Quality Control Standards
121
Fluid Quality Control Method
124
Discussion
125
References
126
Uremic Toxins
127
New Uremic Toxins – Which Solutes Should Be Removed?
127
Abstract
127
Toxicity of Specific Uremic Retention Solutes
128
Removal of Protein-Bound Uremic Solutes and Middle Molecules
133
Interventional Outcome Studies Based on Removal
135
Conclusions
136
References
136
Beta-2-Microglobulin as a Uremic Toxin: the Japanese Experience
139
Abstract
139
ß2-Microglobulin and Dialysis-Related Amyloidosis
139
Therapeutic Approaches
140
Conclusion
142
References
142
Markers and Possible Uremic Toxins: Japanese Experiences
144
Abstract
144
Oxidative Stress and AGEs in ESRD
145
Vitamin E-Coated Dialysis Membrane
146
Clinical Effects of Vitamin E-Coated Dialyzer
146
Conclusion
147
References
147
Dialysis Membranes for Hemodiafiltration
149
Biocompatibility of the Dialysis Membrane
149
Abstract
149
Complement Activation
151
Contact Pathway Activation
151
Platelet Activation
151
Monocyte Activation
152
Neutrophil Activation
154
Conclusion
155
References
155
Choice of Dialyzers for HDF
156
Abstract
156
Materials and Method
158
Results and Discussion
158
Conclusions
161
References
161
Estimation of Internal Filtration Flow Rate in High-Flux Dialyzers by Doppler Ultrasonography
163
Abstract
163
Materials and Methods
164
Results
167
Discussions
170
Conclusions
170
References
171
Clinical Aspects of Hemodiafiltration
172
Management of Anemia by Convective Treatments
172
Abstract
172
Pathogenesis of Anemia in Chronic Kidney Disease
173
Anemia and Dialysis Dose
174
Convective Treatments
175
Vitamin E-Coated Membranes
176
Online Treatments
176
Conclusions
180
References
180
Clinical Evaluation Indices for Hemodialysis/Hemodiafiltration in Japan
183
Abstract
183
Historical Review of Chronic HD Therapy in Japan
184
Influence of the Low Prevalence of Renal Transplantation on Chronic HD Therapy in Japan
184
Impacts of High-Flux Membrane Dialyzers on Clinical Indices of HD Patients
185
Impacts of HDF on the Clinical Indices of HD Patients
187
References
188
Effect of Large-Size Dialysis Membrane and Hemofiltration/Hemodiafiltration Methods on Long-Term Dialysis Patients
189
Abstract
189
Development of Protein-Permeable Dialysis Membrane
190
Removal of Uremic Substances and Loss of Albumin in Low MW Protein Region
191
Clinical Efficiency
192
Conclusion
195
References
197
Who Needs Acetate-Free Biofiltration?
198
Abstract
198
Background
198
Concept of Acetate-Free Biofiltration
198
Indication for AFB
199
AFHD vs. AFB
200
Conclusion
202
References
203
Improvement of Autonomic Nervous Regulation by Blood Purification Therapy Using Acetate-Free Dialysis Fluid – Clinical Evaluation by Laser Doppler Flowmetry
205
Abstract
205
Evaluation of Autonomic Function by NICOMM
206
Stability Index of Tissue Blood Flow in the Head
208
Evaluation of Blood Purification Modalities with the Head SI
209
Conclusions
212
References
213
Preservation of Residual Renal Function with HDF
214
Abstract
214
Background
214
Study 1
215
Study 2
216
Study 3
217
Discussion
220
Acknowledgments
221
References
221
Author Index
223
Subject Index
224
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