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Introduction
7
Contents
9
Contributors
12
I General Strategies for Molecular Targeting in Oncology
16
The Cell Cycle
17
mTOR
47
Ras/Raf/MEK Inhibitors
68
17-AAG
87
The Cancer Epigenome
108
II Molecular Targeting for Specific Disease Sites
125
Molecular Targeting in Upper Gastrointestinal Malignancies
126
Molecular Targeting of Colorectal Cancer
141
Molecular Targeting in Hepatocellular Carcinoma
172
Molecularly Targeted Therapy in Pancreatic Cancer
218
Untargeted Use of Targeted Therapy
234
Renal Cell Carcinoma
248
Targeted Therapies for Prostate Cancer
269
Molecular Targets in Ovarian Cancer and Endometrial Cancer
297
Targeted Therapy For Breast Cancer
315
Melanoma
349
III Classes of Drugs for Molecular Targeting in Oncology
374
Antibody Therapy of Cancer
375
Nucleic Acid Therapies for Cancer Treatment
417
Engineering Oncolytic Measles Viruses for Targeted Cancer Therapy
434
Vaccines as Targeted Cancer Therapy
449
Cytokine-Based Therapy for Cancer
472
Cyclooxygenase-2 as a Target for Cancer Prevention and Treatment
509
IV Specific Drugs for Molecular Targeting in Oncology
542
Imatinib Mesylate (Gleevec and the Emergence of Chemotherapeutic Drug- Resistant Mutations
543
Development of a Targeted Treatment for Cancer
556
VEGF Inhibition for Cancer Therapy
569
Somatostatin Analogue Therapy
581
V Challenges in Molecular Targeting in Oncology
634
Patient Selection for Rational Development of Novel Anticancer Agents
635
Clinical Trial Design with Targeted Agents
643
How to Define Treatment Success or Failure if Tumors Do Not Shrink
650
Molecular Imaging in Oncology
668
Combinations of Molecular- Targeted Therapies
685
Preclinical Development of Molecularly Targeted Agents in Oncology
698
Index
714
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